Endocrine Abstracts

Background: Due to improvements in diagnosis capabilities, there has been a recent increase in adrenal tumors, that are incidentally discovered in patients, who underwent examination by sonography (S), computed tomography (CT) and magnetic resonance imaging (MRI) The aim of this study was to define the usefulness of contrast-enhanced three-dimensional sonography in the diagnosis of nonfunctioning adrenal incidentalomas.Patients and methods<p class="a...

Previously asymptomatic 29-year-old Saudi male patient, presented to with a history of dizziness, abdominal pain and diarrhea for three days.His morning 800 h serum cortisol was 6.4 μg/dl (normal: 5–25 μg/dl); plasma ACTH was 7579 pg/ml (normal: <46.00). The diagnosis of acute adrenal crisis was made which confirmed later by a defective rise in the cortisol level with ACTH stimulation test.The patient was admitte...

Cyclic Cushing’s syndrome (CysCS) is one of the peculiar types of Cushing’s syndrome, characterized by the iteration between remission and recurrence. The precise mechanism in which the hormonal activity is changed suddenly has not been determined, while several hypotheses have been presented. Here, we report a case of CysCS which was induced remission dramatically by dopamine agonist.A 67-years-old woman was pointed out increasing ACTH and cor...

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism between the age 50–65 years (55.00 (50.00; 58.00)) were treated with a 1% testosterone gel within 12 months.Results: Testosterone levels increased from 4.65 (2.70; 6.10) nmol/l at baseline to 13.65 (12.60; 15.20) nmol/l after 48 weeks of treatment (...

Recently, many cases with hypoglycemia who take oral hypoglycemic agents and/or insulin therapy are carried to the emergency room in our hospital due to hypoglycemia. Pharmacotherapy for patients with diabetes mellitus occasionally can causes severe hypoglycemic attack. In this study, we investigated 69 type 2 diabetics on clinical features (26 outpatients of our hospital, 43 outpatients of other clinics) among 100 patients who were carried to the emergency room due to hypogly...

Tc- 99m Sestamibi parathyroid scan (SP scan) is performed to identify location of either hyperplastic or adenomatous gland(s) in primary hyperparathyroidism (HPT). In this study we evaluated diagnostic outcome in 55 consecutive patients with clinical diagnosis of HPT who were referred for SP scans and subsequently had parathyroid surgery. These patients with HPT were of 66.9+12.46 (mean + SD) age, and had serum calcium 10.9+0.93 mg/dl, phosphorus 3.0+0.51 mg/dl, chloride 107+3...

Background: Chromogranin A (CgA) is essential for the formation of secretory granules and sequestration of hormones in neuroendocrine cells. Measurement of CgA levels is included in the diagnostic procedure of neuroendocrine tumors and pheochromocytoma. The aim of this study was to assess the reliability of the Kryptor assay for CgA measurement.Methods: Imprecision of the Kryptor CgA assay was determined with two levels of CgA concentration. Reference va...

Background: A number of studies have evaluated the association between prolactin (PRL) and breast cancer risk, but some results have been inconsistent.The aim of this study was to investigate, if the circadian rhythm of PRL was maintained in pre- and post-menopausal patients with breast cancer and if there is a correlation between serum PRL level, serum concentration of insulin-like growth factor 1 (IGF1), tumor staging and expression of estrogen, proges...

Purpose: For vaginoplasty of Rokitansky syndrome, we use oxidized regenerated cellulose instead of bio-craft that has been used in the past because it requires a less invasive and more physiological surgery. However, the mechanism of epithelialization of this procedure is still not clear. There is a report that differentiation and proliferation of the vaginal epithelium of newborn mice is promoted by administration of basic fibroblast growth factor (bFGF).<p class="abstext...

Introduction: Transsphenoidal surgery (TSS) is the treatment option of first choice for Cushing’s disease (CD). The traditional microsurgical technique has recently been challenged by endoscopic surgical methods. We present endocrine outcome of TSS in CD with a modified contemporary microsurgical concept.Methods: Eighty three patients underwent TSS for newly-diagnosed CD (72 microadenomas and 11 macroadenomas). An enlarged resection was performed in...